Overview
NCBI Entrez MCP Server is a comprehensive MCP implementation that provides access to NCBI APIs, including E-utilities, PubChem PUG, and PMC services, through a single, easy-to-use platform. It works out of the box with zero configuration, so you can clone, install, and start immediately. Optional API key support unlocks higher rate limits: from 3 requests per second to up to 10 per second with a free NCBI API key. The server enforces NCBI rate limits to ensure reliable operation and predictable performance. You can verify behavior with test-rate-limits.js and, when needed, configure the NCBI_API_KEY environment variable. Detailed setup instructions are available in API_KEY_SETUP.md. It also offers several integration paths: connect from Cloudflare AI Playground as a remote MCP client, or use Claude Desktop via the mcp-remote proxy, including code-mode aliases for Cloudflare Code Mode. The README emphasizes accessibility for both technical and non-technical users and provides ready-to-run helpers and docs (docs/codemode.md) to facilitate adoption.
Features
Complete NCBI API Coverage
Provides access to E-utilities, PubChem PUG, and PMC APIs through the MCP server.
No Setup Required
Works out of the box with zero configuration, enabling immediate use after cloning and installing dependencies.
Optional API Key for Higher Rate Limits
Add a free NCBI API key to boost rate limits from 3 to 10 requests per second.
Built-in Rate Limiting Respect
Respects NCBI's rate limits to prevent throttling and provide predictable usage.
User-Friendly Experience
Designed for both technical and non-technical users with straightforward setup and testing.
Who Is This For?
- Researchers:Access and retrieve biomedical data from NCBI Entrez APIs via MCP for research.
- Developers:Integrate NCBI APIs into applications with built-in MCP rate limiting and API key support.
- Nontechnical users:Use Cloudflare Playground or Claude Desktop to access MCP tools without deep technical knowledge.
